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Mutant protein aggregation and misfolding is often correlated with toxicity in neurodegenerative diseases. Aggregate-prone proteins are tagged by ubiquitin that signals them for destruction by the proteasome or autophagy, two key pathways for protein degradation and proteostasis. Here, we review recent studies showing that the regulation of aggregate-prone proteins by ubiquitin signaling is
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Advancement in our knowledge of understanding the roles of HECT E3s requires biochemical tools such as activity-based probes (ABPs). In this study we developed a novel dehydroalanine (Dha)-based E2-Ub ABP using a strategy that is a combination of practical hydrazide-based native chemical ligation and sequential Dha formation.
Jan 31, 2020Jen Hecht is the VP of People Operations at RStudio. She was first introduced to R in 2013, as a non-programmer seeking better ways to manage analytical projects - a quest which was aided both by the RStudio toolchain and the welcoming support of R Ladies, R meetup groups, and other wonderful open resources.
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Jun 22, 2015HECT type ubiquitin ligases all share a homologous C-terminal HECT domain, composed of the N-terminal E2 enzyme-binding lobe and a smaller C-terminal lobe with the catalytic cysteine. A flexible hinge region between the N- and C-lobes bridges both portions of the domain and enables the juxtapositioning of the catalytic sites of E2 and E3
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Dec 16, 2010Applications of machine learning and computational intelligence to drug discovery and development. David Hecht. Corresponding Author. E-mail address: dhechtswccd.edu. Southwestern College, Chula Vista, California. Southwestern College, 900 Otay Lakes Rd., Chula Vista, CA 91910Search for more papers by this author.
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Analysis of protein features and machine learning algorithms for prediction of druggable proteins. Quantitative Biology 2018, 6 (4), 334-343. DOI: 10.1007/s40484-018-0157-2. Yukihiro Itoh. Chemical Protein Degradation Approach and its Application to Epigenetic Targets.
The calculations are performed on the HECT o R phase 2b machine at the unrestricted Hartree–Fock level of theory, with one symmetry operator. In figure 4, the total runtime for a single SCF cycle and the contributions from SHELLX and MPP_DIAG are displayed for cases where a single k point is used.
Ben Hecht (/ h ɛ k t /; February 28, 1893 – April 18, 1964) was an American screenwriter, director, producer, playwright, journalist, and novelist. A journalist in his youth, he went on to write 35 books and some of the most entertaining screenplays and plays in America. He received screen credits, alone or in collaboration, for the stories or screenplays of some seventy films.
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hectoliter (hĕk′tə-lē′tər) n. Abbr. hl A metric unit of volume equal to 100 liters. hec•to•li•ter or hek•to•liter (ˈhɛk təˌli tər) n. a unit of capacity equal to 100 liters (2.8378 U.S. bushels or 26.418 U.S. gallons). Abbr.: hl [1800–10; French hectolitre] ThesaurusAntonymsRelated WordsSynonymsLegend: Switch to new
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Apr 20, 2017The HECT family was first discovered when investigating the function of E6AP, a protein that forms a complex with human papillomavirus E6 oncoprotein types 16 and 18. 9 HECT E3 ligases feature a highly conserved C‐terminal HECT domain of around 350 amino acids; this consists of the E2‐binding N lobe separated from a C lobe (containing the
Jun 23, 2020Moyamoya disease is a genetic disorder affecting both adults and children. It is characterized by narrowing of the blood vessels in the brain, which can lead to strokes. Moyamoya patients often have mutations in the gene for a protein called RNF213. This protein is linked to multiple processes in the body, including the development of blood vessels.
Our new Yale Medicine/Yale New Haven Health COVID-19 Call Center offers information on how to keep yourself and your family healthy. Health professionals are available to answer your questions, Monday – Friday, 7 am – 7 pm. 203-688-1700. For more information about Yale's response to COVID-19, please visit the Research, Clinical, Data Driven Responses to COVID-19 website.
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Then, the ubiquitin is transfer from HECT domain to the lysine residue of the substrate. HECT motif is composed of N-terminal and C-terminal halves separated by a flexible hinge region required for the E3 ligase activity. The N-terminal lobe contains an E2-ubiquitin binding site and the C-terminal lobe includes the active-site cysteine residue .
May 12, 2015HECT type ubiquitin ligases all share a homologous C‐terminal HECT domain, composed of the N‐terminal E2 enzyme‐binding lobe and a smaller C‐terminal lobe with the catalytic cysteine. A flexible hinge region between the N‐ and C‐lobes bridges both portions of the domain and enables the juxtapositioning of the catalytic sites of E2
tical coherence tomography parameters. Methods: We analyzed spectral domain optical coherence tomography data of 153 patients with either pseudophakic cystoid ME (n = 57), diabetic ME (n = 86), or "mixed" (n = 10). We used advanced machine learning algorithms to develop a predictive classifier using the smallest number of parameters. Results: Most differentiating were the existence of hard
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